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torsdag, mars 03, 2022

The Master Circadian Clock

 svensk version här


Mammalian physiology and behavior (and we are mammals) are organized in a daily program that makes a coordinated regulation in the body of light and dark conditions during the day and the night. This organization is also found in most cells in our body as well as circadian clocks (circadian clock). This machinery in the cells consist of genes that regularly express (produce) proteins, which interact in a network in the cell and affect other genes and thereby control the cell's physiology and metabolism. Almost half of all mammalian genes express in this way with a regular rhythm. In modern physiology, the importance of clock genes has been increasingly explored, and it has been found that they are directly involved in sleep disorders, but also in the development of diabetes, cancer, bipolar disorder and other chronic diseases.


 

For this circadian rhythm system to work, all circadian clocks in the body must be in step with each other and with the 24-hour clock; This is what the Master Circadian Clock does. It is like a pacemaker that sends out impulses with some regularity to the body's various cells, glands, organs. This regularity has developed over thousands of years, and from what I understand, it makes it easier for the body if as much as possible is done in a pre-arranged way. When you eat at different times, it signals to the salivary glands, gastric mucosa, duodenum, small intestine, large intestine and rectum in an adapted time sequence and contributes to digestion and absorption of nutrients, waste management  according to the plan that the circadian clock has. Not least, it is important that the body's organs are allowed to rest regularly and heal what has been damaged during the waking period. Sleep is an extremely important repair period for the body and its parts.

The master circadian clock is located in the brain nearby where the optic nerves intersect. And exactly there  the signals from retina come and tell that’s time for the pineal gland to stop producing melatonin - the bright day has begun

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